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Table 1 Details of the Mayo2 samples used in this study and genotype counts

From: Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study

 

Number of samples

Mean Age (SD)

% Female

% ε4+

Series

AD

CON

Total

AD

CON

AD

CON

AD

CON

Jacksonville

507

967

1,474

80.0 (6.7)

81.7 (7.6)

61.9

56.3

60.2

21.8

Rochester

317

1,638

1,955

85.8 (4.5)

80.3 (5.2)

62.1

54.6

42.3

22.4

Autopsy

312

102

414

87.4 (4.8)

86.0 (4.3)

67.6

52.0

61.2

14.7

Norway

346

555

901

80.2 (7.3)

75.3 (6.8)

69.9

59.8

63.0

24.1

Poland

483

188

671

76.7 (4.8)

73.0 (5.9)

66.3

76.6

56.4

19.0

ARUK

669

751

1,420

75.6 (8.2)

76.2 (7.3)

55.6

49.9

58.0

24.4

  1. The number of LOAD patients (AD) and controls (CON), mean age-at-diagnosis, percentage that are female and percentage that possess at least one copy of the APOE ε 4 allele are given for each individual series. Mean age is given as age at diagnosis/entry with the standard deviation (SD) from the mean in parentheses. None of the samples comprising the Jacksonville, Rochester and autopsy-confirmed Mayo Clinic or ARUK series (comprising Bristol, Leeds, Manchester, Nottingham, Oxford and Southampton), which were included in this follow-up study overlap with those used in the Naj et al. study and have not been included in any of the published LOAD GWAS. The Mayo2 dataset included in the Hollingworth et al. publication only included genotypes for ABCA7, MS4A6A and MA4A4E.