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Figure 1 | Molecular Neurodegeneration

Figure 1

From: C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Figure 1

Effect of SIN-1, paraquat and arginine on TDP-43 localization in SH-SY5Y cells. Cells were exposed overnight with 0.1 mM SIN-1, 1 mM paraquat or 1 mM arginine and TDP-43 localization was examined by immunofluorescence. A-C: untreated, D-F: SIN-1, G-I: paraquat, J-L: arginine. Green = TDP-43, blue = DAPI. Right-hand panel = merged images of TDP-43 and DAPI. Arrowheads show diffuse cytosolic TDP-43. Arrows show aggregated cytosolic TDP-43. Bar = 10 μm. Representative images from three separate experiments performed in duplicate or triplicate.

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