Treatment of HeLa cells with sodium arsenite induces JNK-dependent TDP-43 SGs. HeLa cells were treated for 1 hr with 0.5 mM sodium arsenite and cells were examined for TDP-43 and HuR localization by immunofluorescence. A-C: untreated, D-F: sodium arsenite-treated, G-I: sodium arsenite and SP600125. Green = TDP-43, red = HuR, blue = DAPI. Arrows indicate SGs. Bar = 10 μm. Representative images from three separate experiments performed in duplicate or triplicate.