Skip to main content

Table 1 Casp2 expression in the striatum of YAC128 mice and human HD patients

From: Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

Species Age (M) Disease
Stage*
Gene Expression, HD/Control SEM t-value p-value
Mouse 3   Casp2 .704 .063 1.78 > 0.05
Mouse 6   Casp2 1.15 .11 0.56 > 0.05
Mouse 9   Casp2 1.20 .12 0.71 > 0.05
Mouse 12   Casp2 1.01 .12 0.08 > 0.05
Human**   0-2 Casp2 0.996   -0.14 > 0.05
Human**   0-2 HMGCR 0.739   -5.04 < 0.001
  1. Human striatal casp2 mRNA levels were extracted from publically available sources of microarray data (Affymetrix HG-U133A/B probe set 208050_s_at, HDBase.org-originally described in [66]). Mouse striatal casp2 levels were determined using QRT-PCR at 3, 6, 9 and 12 months of age. Casp2 is not upregulated in the striatum of aging YAC128 mice or human HD patients.
  2. * Vonsattel neuropathological score at time of death [3]
  3. ** Human data extracted from [40]