Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

Table 1 Casp2 expression in the striatum of YAC128 mice and human HD patients

Species	Age (M)	Disease Stage*	Gene	Expression, HD/Control	SEM	t-value	p-value
Mouse	3		Casp2	.704	.063	1.78	> 0.05
Mouse	6		Casp2	1.15	.11	0.56	> 0.05
Mouse	9		Casp2	1.20	.12	0.71	> 0.05
Mouse	12		Casp2	1.01	.12	0.08	> 0.05
Human**		0-2	Casp2	0.996		-0.14	> 0.05
Human**		0-2	HMGCR	0.739		-5.04	< 0.001

Human striatal casp2 mRNA levels were extracted from publically available sources of microarray data (Affymetrix HG-U133A/B probe set 208050_s_at, HDBase.org-originally described in [66]). Mouse striatal casp2 levels were determined using QRT-PCR at 3, 6, 9 and 12 months of age. Casp2 is not upregulated in the striatum of aging YAC128 mice or human HD patients.
* Vonsattel neuropathological score at time of death [3]
** Human data extracted from [40]

ISSN: 1750-1326