Figure 5
From: Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
Markers of CREB function and apoptosis in AD-post mortem brain. Post-mortem hippocampal samples (8 each) of AD cases and age-matched controls with equal protein content were electrophoresed, transferred, and immunoprobed with antibodies for markers of CREB function and apoptosis. The blots were reprobed for β actin. Representative images are provided. Decreases in CREB-regulated proteins that improve neuronal survival and increases in the levels of the active form of caspase-9, a marker for the intrinsic pathway of apoptosis were observed in AD-post mortem brain.