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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Figure 6

Markers of oxidative stress in AD-post mortem brain. (A) Post-mortem hippocampal samples (8 each) of AD cases and age-matched controls with equal protein content were immunoblotted for GFAP and HNE, markers of oxidative stress. Representative images are provided. There was accumulation of markers of oxidative stress in AD brain. (B) Post-mortem samples were treated with 2,4-dinitrophenylhydrazine (DNPH) to form DNP-hydrazone. DNP-derivatized protein samples were electrophoresed and immunoblotted with anti-DNP antibody. Oxidative modification of proteins was elevated in AD brain samples.

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