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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

Figure 2

Rs3846662 is significantly associated with percent HMGCRΔ13 in human liver. Individuals homozygous for the G allele of rs3846662 exhibit the most efficient splicing of HMGCR exon 13 (p = 0.026, ANOVA. We note that GG homozygotes also exhibit an increased risk of AD and exhibit increased total and LDL cholesterol.

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Molecular Neurodegeneration

ISSN: 1750-1326