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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

Figure 6

Rs3846662 functionally modulates percent HMGCRΔ13 in vitro in HepG2 and H4 cells. Cells were transfected with HMGCR exon 12-14 mini-genes that contained either the A or G allele of rs3846662. Vector-derived HMGCR isoforms were separated by PAGE and visualized by using SYGR-gold fluorescence (A). The G allele of rs3846662 was consistently associated with increased retention of HMGCR exon 13 in both HepG2 (B) and H4 (C) cell lines relative to the A allele (p = 0.02, Student's paired t-test).

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Molecular Neurodegeneration

ISSN: 1750-1326