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Table 1 Phase 1 analysis of association between cholesterol SNPs and AD.

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

CHR

GENE

SNP

OR

L95

U95

P

19

APOE

rs157580

0.51

0.45

0.59

3.30E-21

5

HMGCR

rs3846662

1.16

1.02

1.32

0.02

12

MMAB/MVK

rs7298565

0.88

0.78

1

0.05

5

TIMD4/HAVCR1

rs1363232

0.89

0.78

1.01

0.06

15

LIPC

rs1532085

0.89

0.78

1.01

0.07

16

CETP

rs9989419

1.12

0.98

1.27

0.09

19

NCAN

rs2304130

1.16

0.92

1.47

0.21

20

HNF4A

rs1800961

0.8

0.55

1.16

0.24

18

LIPG

rs4939883

1.09

0.92

1.28

0.32

16

LCAT

rs2271293

0.91

0.75

1.1

0.33

1

SORT1

rs646776

1.07

0.92

1.24

0.4

1

GALNT2

rs10779835

0.95

0.84

1.08

0.44

9

TTC39B

rs471364

1.07

0.88

1.3

0.48

2

APOB

rs506585

1.05

0.9

1.23

0.53

19

LDLR

rs2228671

0.96

0.79

1.17

0.66

2

APOB

rs693

0.98

0.87

1.11

0.78

16

CETP

rs3764261

0.99

0.86

1.13

0.86

9

ABCA1

rs3847303

0.99

0.82

1.19

0.92

  1. Overall, the seventeen SNPs not in linkage with APOE exhibited a global association with AD by using multivariable logistic regression (p = 0.017). Two SNPs, not including rs157580 (which marks APOE), were nominally associated with AD per additive logistic regression modeling (p ≤ 0.05). Three other SNPs showed a trend with AD (p < 0.1).