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Table 1 Phase 1 analysis of association between cholesterol SNPs and AD.

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

CHR GENE SNP OR L95 U95 P
19 APOE rs157580 0.51 0.45 0.59 3.30E-21
5 HMGCR rs3846662 1.16 1.02 1.32 0.02
12 MMAB/MVK rs7298565 0.88 0.78 1 0.05
5 TIMD4/HAVCR1 rs1363232 0.89 0.78 1.01 0.06
15 LIPC rs1532085 0.89 0.78 1.01 0.07
16 CETP rs9989419 1.12 0.98 1.27 0.09
19 NCAN rs2304130 1.16 0.92 1.47 0.21
20 HNF4A rs1800961 0.8 0.55 1.16 0.24
18 LIPG rs4939883 1.09 0.92 1.28 0.32
16 LCAT rs2271293 0.91 0.75 1.1 0.33
1 SORT1 rs646776 1.07 0.92 1.24 0.4
1 GALNT2 rs10779835 0.95 0.84 1.08 0.44
9 TTC39B rs471364 1.07 0.88 1.3 0.48
2 APOB rs506585 1.05 0.9 1.23 0.53
19 LDLR rs2228671 0.96 0.79 1.17 0.66
2 APOB rs693 0.98 0.87 1.11 0.78
16 CETP rs3764261 0.99 0.86 1.13 0.86
9 ABCA1 rs3847303 0.99 0.82 1.19 0.92
  1. Overall, the seventeen SNPs not in linkage with APOE exhibited a global association with AD by using multivariable logistic regression (p = 0.017). Two SNPs, not including rs157580 (which marks APOE), were nominally associated with AD per additive logistic regression modeling (p ≤ 0.05). Three other SNPs showed a trend with AD (p < 0.1).