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Table 3 Phase 3 analysis of association between cholesterol SNPs and AD.

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

CHR GENE SNP OR L95 U95 P
5 HMGCR rs3846662 1.12 1.04 1.21 0.004
15 LIPC rs1532085 0.92 0.85 0.99 0.03
12 MMAB/MVK rs7298565 0.99 0.92 1.07 0.88
  1. Phase 1 and Phase 2 populations were combined to allow for testing of SNP-AD associations under maximal power (80% for rs3846662 and 98% for rs1532085). Both rs3846662 and rs1532085 exhibited significant associations with AD in this combined population per logistic regression (p ≤ 0.05).