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Table 3 Phase 3 analysis of association between cholesterol SNPs and AD.

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

CHR

GENE

SNP

OR

L95

U95

P

5

HMGCR

rs3846662

1.12

1.04

1.21

0.004

15

LIPC

rs1532085

0.92

0.85

0.99

0.03

12

MMAB/MVK

rs7298565

0.99

0.92

1.07

0.88

  1. Phase 1 and Phase 2 populations were combined to allow for testing of SNP-AD associations under maximal power (80% for rs3846662 and 98% for rs1532085). Both rs3846662 and rs1532085 exhibited significant associations with AD in this combined population per logistic regression (p ≤ 0.05).
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Molecular Neurodegeneration

ISSN: 1750-1326