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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Alzheimer's disease: synapses gone cold

Figure 2

Oligomeric Aβ associates with a subset of synapses in the brain of Alzheimer's disease transgenic mice. A) Array tomograms showing oligomeric Aβ (oAβ) localized to synaptic sites near senile plaques in APP/PS1 mice. B) A higher magnification view of the outlined square in panel A showing multiple pre- and post-synaptic elements colocalized with oAβ (arrows) stained with an oAβ specific antibody (NAB61). Scale bar is 10 μm in A and 2 μm in B.

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Molecular Neurodegeneration

ISSN: 1750-1326