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Table 1 Enriched KEGG pathways among the 115 changed transcripts

From: Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease

KEGG pathway Genes in pathway Enrichment
B cell receptor signaling pathway BLNK, CD19, CD22, CD72, CD79A, CD79B, CR2, RASGRP3 O = 8;E = 0.419;R = 19.111;P = 2.21e-8
Hematopoietic cell lineage CD19, CD22, CD8B, CR2, FCER2, IL1R2 O = 6;E = 0.546;R = 10.995;P = 2.60e-5
Type II diabetes mellitus CACNA1C, CACNA1D, IRS2 O = 3;E = 0.284;R = 10.560;P = 3.45e-3
Calcium signaling pathway ADCY2, CACNA1C, CACNA1D, GNAL, P2RX5 O = 5;E = 1.114;R = 4.489;P = 5.78e-3
MAPK signaling pathway CACNA1C, CACNA1D, CACNB4, IL1R2, RASGRF1, RASGRP3 O = 6;E = 1.779;R = 3.373;P = 9.64e-3
ABC transporters - General ABCA13, ABCB4 O = 2;E = 0.254;R = 7.868;P = 2.92e-2
GnRH signaling pathway ADCY2, CACNA1C, CACNA1D O = 3;E = 0.650;R = 4.613;P = 2.93e-2
Cell adhesion molecules (CAMs) CD22, CD40, CD8B O = 3;E = 0.807;R = 3.716;P = 4.95e-2
  1. O, Observed number of genes carrying the annotation among the 115 differentially expressed genes; E, expected number of genes that carry this annotation among all core-level genes on the array; R, ratio between observed and expected; P, P-value of the enrichment, calculated using Fisher exact test.