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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

Figure 8

Patterns of CRMP2 immunoreactivity in the hippocampus of an HIV encephalitis brain and a gp120 transgenic mouse brain. Forty μm-thick vibratome sections from the brains of HIV encephalitis (HIVE) patients and gp120 transgenic (tg) mice were processed for double-immunolabeling analysis with antibodies against doublecortin (DCX) and CRMP2. (A-C) Intracellular CRMP2 immunoreactivity was detected throughout cells in the granular cell layer (GCL) and into the molecular layer (ML) of the hippocampal dentate gyrus in a representative section from the brain of a patient with HIVE. A subset of DCX-positive cells in the subgranular zone (SGZ) co-expressed CRMP2 (arrows). (D-F) Intracellular CRMP2 immunoreactivity was detected throughout cells in the granular cell layer (GCL) and into the molecular layer (ML) of the hippocampal dentate gyrus in a representative section from the brain of a gp120 tg mouse. A subset of DCX-positive cells in the subgranular zone (SGZ) co-expressed CRMP2 (arrows). Scale bar = 15 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326