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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Figure 1

tPA increases NMDA-mediated neurotoxicity in cortical neuronal cultures but not in hippocampal neuronal cultures. Cortical and hippocampal neurons were exposed to NMDA (10 μM) with or without tPA (20 μg/mL) for 24 hours. (A) Bright field photomicrographs of cultures stained by peroxidase with a MAP2 immunostaining, scale bar 100 μm. (B) Quantification of neuronal death by LDH release: tPA increased excitotoxic neuronal death in cortical but not in hippocampal cultures (n = 12; *p < 0.05; NS: not significant).

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Molecular Neurodegeneration

ISSN: 1750-1326