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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Figure 2

Memantine and PPDA protect neurons from NMDA-mediated neurotoxicity in both cortical and hippocampal cultures. Cortical (A, C) and hippocampal (B, D) neurons were exposed to NMDA (10 μM) with or without memantine (A, B) or PPDA (C, D). At the lowest doses, memantine (1 μM) and PPDA (0.02 μM) failed to protect both types of neurons, but at the highest doses, memantine (10 μM) and PPDA (0.2 μM) were able to protect cortical and hippocampal neurons from excitotoxicity (A: n = 12, B: n = 11, C: n = 16, D: n = 9; *p < 0.05; NS: not significant).

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Molecular Neurodegeneration

ISSN: 1750-1326