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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Figure 3

UBP145 has no effect on NMDA-mediated neurotoxicity in hippocampal neurons but prevents tPA-induced potentiation of NMDA-mediated neurotoxicity in cortical neurons. Cortical (A, C) and hippocampal (B) neurons were exposed to NMDA (10 μM) with or without UBP145 and tPA (20 μg/mL) for 24 hours. Quantification of neuronal death by LDH release in the medium: (A, B) UBP145 2 μM protected cortical but not hippocampal neurons from neurotoxicity, (C) although UBP145 0.2 μM did not protect cortical neurons from excitotoxicity, it was able to prevent tPA-induced potentiation of excitotoxicity (n = 12; *p < 0.05; NS: not significant).

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