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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Figure 5

In vivo, UBP145 can fully prevent the pro-excitotoxic effect of intravenously administered tPA. Cortical injections of NMDA (2.5 nmoles; in 0.33 μl), alone or with UBP145 (0.05 nmoles) were performed in mice using a stereotaxic frame. (A) When UBP145 was co-injected with NMDA, it prevented tPA-induced potentiation of the excitotoxic lesion (n = 6 per group, **p < 0.01; NS: not significant). (B) When UBP145 was administered intravenously, it was not able to reduce NMDA-induced excitotoxic lesion (n = 5 per group; NS: not significant). Scale bar: 400 μm

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Molecular Neurodegeneration

ISSN: 1750-1326