The influence of chronic dimebolin treatment on spatial memory in TgCRND8 and wild type mice in the Morris water maze test. (A, D) Hidden platform acquisition from TgCRND8 mice (A) and strain-, age-, gender - matched wild type mice (D). Latency score represents the time taken to escape to the platform from the water. (B, E) Probe trials for TgCRND8 mice (B) and wild type mice (E) expressed as percentage of time spent in the target quadrant. Percent of time in target quadrant is calculated as the ratio of time spent in the target quadrant area relative to the time spent in the rest of the pool; (C, F) Probe trials for TgCRND8 mice (C) and wild type mice (F) expressed as platform crossing. Platform crossing is calculated as the times the animals cross the target platform.