The transgene pGFAP-BDNF delays clasping reflex alterations in R6/2 mice. Body weights (A) of wt, pGFAP-BDNF, R6/2 and R6/2:pGFAP-BDNF mice were monitored weekly from 5 to 13 weeks of age. Muscular strength (B) was measured at 7, 10 and 12 weeks of age by the hiring wire test. Clasping level (C) was assessed weekly from 7 to 13 weeks of age. Values are expressed as mean ± s.e.m. Data were analyzed by two-way ANOVA with repeated measurements for body weight and muscular strength. Clasping level was measured by the U Mann-Whitney test. * p < 0.05, ** p < 0.01 and *** p < 0.001, as compared to wt mice; $ p < 0.05, $$ p < 0.01 and $$$ p < 0.001, as compared to pGFAP-BDNF mice; and # p < 0.05, as compared to R6/2:pGFAP-BDNF mice (n = 10-12/genotype).