The transgene pGFAP-BDNF counteracts synaptic fatigue in cortico-striatal connections. Population spike (PS) amplitudes for a given range of stimulus intensities are shown from 12-week-old wt, pGFAP-BDNF, R6/2 and R6/2:pGFAP-BDNF mice (A). Synaptic fatigue using PS recordings was evoked by a four-stimulus train at 100 Hz (B). The PS response at the fourth initial stimulus was calculated as the percentage of the first PS amplitude. Long-term potentiation (LTP) was induced by high-frequency conditioning tetanus (C). Values are expressed as mean ± s.e.m except for C, where error bars are deleted for greater clarity. ** p < 0.01 and *** p < 0.001, for 100% control; # p < 0.05 and ## p < 0.01 for R6/2 mice (n = 8 slices/genotype (at least 3 animals in each case)).