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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

Figure 5

Neuropathology in TDP-43 M337V mice. Hematoxylin and eosin staining revealed (A, arrows) eosinophilic aggregates in spinal motor neurons from TDP-43M337V mice that are not observed in (B) NT mice. Abnormal ubiquitin immunoreactivity was present in the cytoplasm and nucleus of neurons in the (C) spinal cord of TDP-43M337V mice, but not in (D) NT mice. Similar ubiquitination was observed in the (E) cortex of TDP-43M337V mice, but not in (F) NT mice. Enhanced (G-H) GFAP and (I-J) IBA-1 immunoreactivity indicative of reactive astrogliosis and activated microglia, respectively, were observed in TDP-43M337V mice (G, I), but not NT mice (H, J). Scale bars: 100 μM.

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