Neuropathology in TDP-43
mice. Hematoxylin and eosin staining revealed (A, arrows) eosinophilic aggregates in spinal motor neurons from TDP-43M337V mice that are not observed in (B) NT mice. Abnormal ubiquitin immunoreactivity was present in the cytoplasm and nucleus of neurons in the (C) spinal cord of TDP-43M337V mice, but not in (D) NT mice. Similar ubiquitination was observed in the (E) cortex of TDP-43M337V mice, but not in (F) NT mice. Enhanced (G-H) GFAP and (I-J) IBA-1 immunoreactivity indicative of reactive astrogliosis and activated microglia, respectively, were observed in TDP-43M337V mice (G, I), but not NT mice (H, J). Scale bars: 100 μM.