Chromatolysis in TDP-43
mice. Nissl staining of motor neurons of (A) TDP-43M337V mice is much weaker than that in (B) NT mice. (C) Electron micrograph of a chromatolytic neuron of TDP-43M337V mice compared to the (D) normal neuron of the NT mouse shows rarefaction of cytoplasmic organelles (E), compared with the normal cytoplasmic density (D) and packed organelles (F) of NT mice. Scale bars: 20 μM in A and B; 5 μM in C and D; and 1 μM in E and F.