Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

Table 1 Regional distribution of pathologies in TDP-43_M337V mice

	Cortex, layer V	Hippocampus	Striatum	Brainstem	Cerebellum	Anterior horn of spinal cord	Posterior horn of spinal cord
Cytoplasmic TDP-43	+	-	-	+	-	++	+
Nuclear pTDP-43	-	-	-	+/-	-	++	+
Cytoplasmic pTDP-43	++	-	-	+	-	++	+
Ubiquitination	++	+	+	++	-	++	++
IBA-1-positive microglia	+	-	-	++	-	++	+
GFAP-positive astrocytes	+	-	-	++	-	++	+
Mitochondrial aggregates	+	-	-	+	-	++	+
p-tau	++	++	+	+	-	+/-	+/-

ISSN: 1750-1326