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Table 1 Regional distribution of pathologies in TDP-43M337V mice

From: Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

  Cortex, layer V Hippocampus Striatum Brainstem Cerebellum Anterior horn of spinal cord Posterior horn of spinal cord
Cytoplasmic TDP-43 + - - + - ++ +
Nuclear pTDP-43 - - - +/- - ++ +
Cytoplasmic pTDP-43 ++ - - + - ++ +
Ubiquitination ++ + + ++ - ++ ++
IBA-1-positive microglia + - - ++ - ++ +
GFAP-positive astrocytes + - - ++ - ++ +
Mitochondrial aggregates + - - + - ++ +
p-tau ++ ++ + + - +/- +/-