TY - JOUR AU - Anjum, R. AU - Blenis, J. PY - 2008 DA - 2008// TI - The RSK family of kinases: emerging roles in cellular signaling JO - Nat Rev Mol Cell Biol VL - 9 UR - https://doi.org/10.1038/nrm2509 DO - 10.1038/nrm2509 ID - Anjum2008 ER - TY - JOUR AU - Chen, R. H. AU - Sarnecki, C. AU - Blenis, J. PY - 1992 DA - 1992// TI - Nuclear localization and regulation of erk- and rsk-encoded protein kinases JO - Mol Cell Biol VL - 12 UR - https://doi.org/10.1128/MCB.12.3.915 DO - 10.1128/MCB.12.3.915 ID - Chen1992 ER - TY - JOUR AU - Jensen, C. J. AU - Buch, M. B. AU - Krag, T. O. AU - Hemmings, B. A. AU - Gammeltoft, S. AU - Frödin, M. PY - 1999 DA - 1999// TI - 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1 JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.38.27168 DO - 10.1074/jbc.274.38.27168 ID - Jensen1999 ER - TY - JOUR AU - Frödin, M. AU - Gammeltoft, S. PY - 1999 DA - 1999// TI - Role and regulation of 90-kDa ribosomal S6 kinase (RSK) in signal transduction JO - Mol Cell Endocrinol VL - 151 UR - https://doi.org/10.1016/S0303-7207(99)00061-1 DO - 10.1016/S0303-7207(99)00061-1 ID - Frödin1999 ER - TY - JOUR AU - Tan, Y. AU - Ruan, H. AU - Demeter, M. R. AU - Comb, M. J. PY - 1999 DA - 1999// TI - p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.49.34859 DO - 10.1074/jbc.274.49.34859 ID - Tan1999 ER - TY - JOUR AU - Sutherland, C. AU - Leighton, I. A. AU - Cohen, P. PY - 1993 DA - 1993// TI - Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling JO - Biochem J VL - 296 UR - https://doi.org/10.1042/bj2960015 DO - 10.1042/bj2960015 ID - Sutherland1993 ER - TY - JOUR AU - Anjum, R. AU - Roux, P. P. AU - Ballif, B. A. AU - Gygi, S. P. AU - Blenis, J. PY - 2005 DA - 2005// TI - The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling JO - Curr Biol VL - 15 UR - https://doi.org/10.1016/j.cub.2005.08.050 DO - 10.1016/j.cub.2005.08.050 ID - Anjum2005 ER - TY - JOUR AU - Xing, J. AU - Ginty, D. D. AU - Greenberg, M. E. PY - 1996 DA - 1996// TI - Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase JO - Science VL - 273 UR - https://doi.org/10.1126/science.273.5277.959 DO - 10.1126/science.273.5277.959 ID - Xing1996 ER - TY - JOUR AU - Rivera, V. M. AU - Miranti, C. K. AU - Misra, R. P. AU - Ginty, D. D. AU - Chen, R. H. AU - Blenis, J. AU - Greenberg, M. E. PY - 1993 DA - 1993// TI - A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity JO - Mol Cell Biol VL - 13 UR - https://doi.org/10.1128/MCB.13.10.6260 DO - 10.1128/MCB.13.10.6260 ID - Rivera1993 ER - TY - JOUR AU - Ghoda, L. AU - Lin, X. AU - Greene, W. C. PY - 1997 DA - 1997// TI - The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaB alpha and stimulates its degradation in vitro JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.34.21281 DO - 10.1074/jbc.272.34.21281 ID - Ghoda1997 ER - TY - JOUR AU - Schouten, G. J. AU - Vertegaal, A. C. AU - Whiteside, S. T. AU - Israël, A. AU - Toebes, M. AU - Dorsman, J. C. AU - van der EB, A. J. AU - Zantema, A. PY - 1997 DA - 1997// TI - IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase JO - EMBO J VL - 16 UR - https://doi.org/10.1093/emboj/16.11.3133 DO - 10.1093/emboj/16.11.3133 ID - Schouten1997 ER - TY - JOUR AU - Ginty, D. D. AU - Bonni, A. AU - Greenberg, M. E. PY - 1994 DA - 1994// TI - Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB JO - Cell VL - 77 UR - https://doi.org/10.1016/0092-8674(94)90055-8 DO - 10.1016/0092-8674(94)90055-8 ID - Ginty1994 ER - TY - JOUR AU - Bonni, A. AU - Brunet, A. AU - West, A. E. AU - Datta, S. R. AU - Takasu, M. A. AU - Greenberg, M. E. PY - 1999 DA - 1999// TI - Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms JO - Science VL - 286 UR - https://doi.org/10.1126/science.286.5443.1358 DO - 10.1126/science.286.5443.1358 ID - Bonni1999 ER - TY - JOUR AU - Kharebava, G. AU - Makonchuk, D. AU - Kalita, K. B. AU - Zheng, J. J. AU - Hetman, M. PY - 2008 DA - 2008// TI - Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival JO - J Neurosci VL - 28 UR - https://doi.org/10.1523/JNEUROSCI.2135-08.2008 DO - 10.1523/JNEUROSCI.2135-08.2008 ID - Kharebava2008 ER - TY - JOUR PY - 1993 DA - 1993// TI - A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes JO - Cell VL - 72 UR - https://doi.org/10.1016/0092-8674(93)90585-E DO - 10.1016/0092-8674(93)90585-E ID - ref15 ER - TY - JOUR AU - Reiner, A. AU - Albin, R. L. AU - Anderson, K. D. AU - D'Amato, C. J. AU - Penney, J. B. AU - Young, A. B. PY - 1998 DA - 1998// TI - Differential loss of striatal projection neurons in Huntington disease JO - Proc Natl Acad Sci USA VL - 85 UR - https://doi.org/10.1073/pnas.85.15.5733 DO - 10.1073/pnas.85.15.5733 ID - Reiner1998 ER - TY - JOUR AU - Gines, S. AU - Ivanova, E. AU - Seong, I. S. AU - Saura, C. A. AU - MacDonald, M. E. PY - 2003 DA - 2003// TI - Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M309348200 DO - 10.1074/jbc.M309348200 ID - Gines2003 ER - TY - JOUR AU - Gines, S. AU - Paoletti, P. AU - Alberch, J. PY - 2010 DA - 2010// TI - Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M109.084202 DO - 10.1074/jbc.M109.084202 ID - Gines2010 ER - TY - JOUR AU - Maher, P. AU - Dargusch, R. AU - Bodai, L. AU - Gerard, P. E. AU - Purcell, J. M. AU - Marsh, J. L. PY - 2011 DA - 2011// TI - ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease JO - Hum Molec Genet VL - 20 UR - https://doi.org/10.1093/hmg/ddq460 DO - 10.1093/hmg/ddq460 ID - Maher2011 ER - TY - JOUR AU - Scotter, E. L. AU - Goodfellow, C. E. AU - Graham, E. S. AU - Dragunow, M. AU - Glass, M. PY - 2010 DA - 2010// TI - Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease JO - Br J Pharmacol VL - 160 UR - https://doi.org/10.1111/j.1476-5381.2010.00773.x DO - 10.1111/j.1476-5381.2010.00773.x ID - Scotter2010 ER - TY - JOUR AU - Apostol, B. L. AU - Illes, K. AU - Pallos, J. AU - Bodai, L. AU - Wu, J. AU - Strand, A. AU - Schweitzer, E. S. AU - Olson, J. M. AU - Kazantsev, A. AU - Marsh, J. L. AU - Thompson, L. M. PY - 2006 DA - 2006// TI - Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity JO - Hum Molec Genet VL - 15 UR - https://doi.org/10.1093/hmg/ddi443 DO - 10.1093/hmg/ddi443 ID - Apostol2006 ER - TY - JOUR AU - Mangiarini, L. AU - Sathasivam, K. AU - Seller, M. AU - Cozens, B. AU - Harper, A. AU - Hetherington, C. AU - Lawton, M. AU - Trottier, Y. AU - Lehrach, H. AU - Davies, S. W. AU - Bates, G. P. PY - 1996 DA - 1996// TI - Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice JO - Cell VL - 87 UR - https://doi.org/10.1016/S0092-8674(00)81369-0 DO - 10.1016/S0092-8674(00)81369-0 ID - Mangiarini1996 ER - TY - JOUR AU - Sapkota, G. P. AU - Cummings, L. AU - Newell, F. S. AU - Armstrong, C. AU - Bain, J. AU - Frodin, M. AU - Grauert, M. AU - Hoffmann, M. AU - Schnapp, G. AU - Steegmaier, L. AU - Cohen, P. AU - Alessi, D. R. PY - 2007 DA - 2007// TI - BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo JO - Biochem J VL - 401 UR - https://doi.org/10.1042/BJ20061088 DO - 10.1042/BJ20061088 ID - Sapkota2007 ER - TY - JOUR AU - Menalled, L. B. PY - 2005 DA - 2005// TI - Knock-in mouse models of Huntington's disease JO - NeuroRx VL - 2 UR - https://doi.org/10.1602/neurorx.2.3.465 DO - 10.1602/neurorx.2.3.465 ID - Menalled2005 ER - TY - JOUR AU - Wheeler, V. C. AU - Auerbach, W. AU - White, J. K. AU - Srinidhi, J. AU - Auerbach, A. AU - Ryan, A. AU - Duyao, M. A. AU - Vrbanac, V. AU - Weaver, M. AU - Gusella, J. F. AU - Joyner, A. L. AU - MacDonald, M. E. PY - 1999 DA - 1999// TI - Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse JO - Hum Molec Genet VL - 8 UR - https://doi.org/10.1093/hmg/8.1.115 DO - 10.1093/hmg/8.1.115 ID - Wheeler1999 ER - TY - JOUR AU - Fossale, E. AU - Wheeler, W. C. AU - Vrbanac, V. AU - Lebel, L. A. AU - Teed, A. AU - Mysore, J. S. AU - Gusella, J. F. AU - MacDonald, M. E. AU - Persichetti, E. PY - 2002 DA - 2002// TI - Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice JO - Hum Molec Genet VL - 11 UR - https://doi.org/10.1093/hmg/11.19.2233 DO - 10.1093/hmg/11.19.2233 ID - Fossale2002 ER - TY - JOUR AU - Panov, A. V. AU - Gutekunst, C. A. AU - Leavitt, B. R. AU - Hayden, M. R. AU - Burke, J. R. AU - Strittmatter, W. J. AU - Greenamyre, J. T. PY - 2002 DA - 2002// TI - Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines JO - Nat Neurosci VL - 5 ID - Panov2002 ER - TY - JOUR AU - Perez-Navarro, E. AU - Canals, J. M. AU - Gines, S. AU - Alberch, J. PY - 2006 DA - 2006// TI - Cellular and molecular mechanisms involved in the selective vulnerability of striatal projection neurons in Huntington's disease JO - Histol Histopathol VL - 21 ID - Perez-Navarro2006 ER - TY - JOUR AU - Trettel, F. AU - Rigamonti, D. AU - Hilditch-Maguire, P. AU - Wheller, V. C. AU - Sharp, A. H. AU - Persichetti, F. AU - Cattaneo, E. AU - MacDonald, M. E. PY - 2000 DA - 2000// TI - Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells JO - Hum Molec Genet VL - 9 UR - https://doi.org/10.1093/hmg/9.19.2799 DO - 10.1093/hmg/9.19.2799 ID - Trettel2000 ER - TY - JOUR AU - Humbert, S. AU - Bryson, E. A. AU - Cordelières, F. P. AU - Connors, N. C. AU - Datta, S. R. AU - Finkbeiner, S. AU - Greenberg, M. E. AU - Saudou, F. PY - 2002 DA - 2002// TI - The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt JO - Dev Cell VL - 2 UR - https://doi.org/10.1016/S1534-5807(02)00188-0 DO - 10.1016/S1534-5807(02)00188-0 ID - Humbert2002 ER - TY - JOUR AU - Saavedra, A. AU - García-Mártinez, J. M. AU - Xifró, X. AU - Giralt, A. AU - Torres-Peraza, J. F. AU - Canals, J. M. AU - Díaz-Hernandez, M. AU - Lucas, J. J. AU - Alberch, J. AU - Pérez-Navarro, E. PY - 2010 DA - 2010// TI - PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum JO - Cell Death Differ VL - 17 UR - https://doi.org/10.1038/cdd.2009.127 DO - 10.1038/cdd.2009.127 ID - Saavedra2010 ER - TY - JOUR AU - Rangone, H. AU - Poizat, G. AU - Troncoso, J. AU - Ross, C. A. AU - MacDonald, M. E. AU - Saudou, F. AU - Humbert, S. PY - 2004 DA - 2004// TI - The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin JO - Eur J Neurosci VL - 19 UR - https://doi.org/10.1111/j.0953-816X.2003.03131.x DO - 10.1111/j.0953-816X.2003.03131.x ID - Rangone2004 ER - TY - JOUR AU - Choen, M. S. AU - Hadjivassiliou, H. AU - Taunton, J. PY - 2007 DA - 2007// TI - A clickable inhibitor reveals context-dependent autoactivation of p90 RSK JO - Nat Chem Biol VL - 3 UR - https://doi.org/10.1038/nchembio859 DO - 10.1038/nchembio859 ID - Choen2007 ER - TY - JOUR AU - Williams, M. R. AU - Arthur, J. S. AU - Balendran, A. AU - van der Kaay, J. AU - Poli, V. AU - Cohen, P. AU - Alessi, D. R. PY - 2000 DA - 2000// TI - The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells JO - Curr Biol VL - 10 UR - https://doi.org/10.1016/S0960-9822(00)00441-3 DO - 10.1016/S0960-9822(00)00441-3 ID - Williams2000 ER - TY - JOUR AU - Zuccato, C. AU - Ciammola, A. AU - Rigamonti, D. AU - Leavitt, B. R. AU - Goffredo, D. AU - Conti, L. AU - MacDonald, M. E. AU - Friedlander, R. M. AU - Silani, V. AU - Hayden, M. R. AU - Timmusk, T. AU - Sipione, S. AU - Cattaneo, E. PY - 2001 DA - 2001// TI - Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease JO - Science VL - 293 UR - https://doi.org/10.1126/science.1059581 DO - 10.1126/science.1059581 ID - Zuccato2001 ER - TY - JOUR AU - Zuccato, C. AU - Cattaneo, E. PY - 2009 DA - 2009// TI - Brain-derived neurotrophic factor in neurodegenerative diseases JO - Nat Rev Neurol VL - 5 UR - https://doi.org/10.1038/nrneurol.2009.54 DO - 10.1038/nrneurol.2009.54 ID - Zuccato2009 ER - TY - JOUR AU - De Cesare, D. AU - Jacquot, S. AU - Hanauer, A. AU - Sassone-Corsi, P. PY - 1998 DA - 1998// TI - Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene JO - Proc Natl Acad Sci USA VL - 95 UR - https://doi.org/10.1073/pnas.95.21.12202 DO - 10.1073/pnas.95.21.12202 ID - De Cesare1998 ER - TY - JOUR AU - Giralt, A. AU - Rodrigo, T. M. AU - Martin, E. D. AU - Gonzalez, J. R. AU - Mila, M. AU - Ceña, V. AU - Dierssen, M. AU - Canals, J. M. AU - Alberch, J. PY - 2009 DA - 2009// TI - Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression JO - Neuroscience VL - 158 UR - https://doi.org/10.1016/j.neuroscience.2008.11.024 DO - 10.1016/j.neuroscience.2008.11.024 ID - Giralt2009 ER - TY - JOUR AU - Giordano, M. AU - Takashima, H. AU - Herranz, A. AU - Polotorak, M. AU - Geller, H. M. AU - Marone, M. AU - Freed, W. J. PY - 1993 DA - 1993// TI - Immortalized GABAergic cell lines derived from rat striatum using a temperature-sensitive allele of the SV40 large T antigen JO - Exp Neurol VL - 124 UR - https://doi.org/10.1006/exnr.1993.1213 DO - 10.1006/exnr.1993.1213 ID - Giordano1993 ER - TY - JOUR AU - Gratacos, E. AU - Checa, N. AU - Perez-Navarro, E. AU - Alberch, J. PY - 2001 DA - 2001// TI - Brain-derived neurotrophic factor (BDNF) mediates bone morphogenetic protein-2 (BMP-2) effects on cultured striatal neurones JO - J Neurochem VL - 79 UR - https://doi.org/10.1046/j.1471-4159.2001.00570.x DO - 10.1046/j.1471-4159.2001.00570.x ID - Gratacos2001 ER - TY - JOUR AU - Xifro, X. AU - Garcia-Martinez, J. M. AU - del Toro, D. AU - Alberch, J. AU - Perez-Navarro, E. PY - 2008 DA - 2008// TI - Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells JO - J Neurochem VL - 105 UR - https://doi.org/10.1111/j.1471-4159.2008.05252.x DO - 10.1111/j.1471-4159.2008.05252.x ID - Xifro2008 ER - TY - JOUR AU - Del Toro, D. AU - Canals, J. M. AU - Gines, S. AU - Kojima, M. AU - Egea, G. AU - Alberch, J. PY - 2006 DA - 2006// TI - Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism JO - J Neurosci VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.3873-06.2006 DO - 10.1523/JNEUROSCI.3873-06.2006 ID - Del Toro2006 ER - TY - JOUR AU - Sapkota, G. P. AU - Kieloch, A. AU - Lizcano, J. M. AU - Lain, S. AU - Arthur, J. S. AU - Williams, M. R. AU - Morrice, N. AU - Deak, M. AU - Alessi, D. R. PY - 2001 DA - 2001// TI - Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M009953200 DO - 10.1074/jbc.M009953200 ID - Sapkota2001 ER -