Figure 6

Effects of fractalkine or immunoneutralizing anti-CX ₃ CR1 antibodies on morphine and/or Tat-induced degeneration of MAP2-immunoreactive dendrites of striatal neurons at 72 h (A-E). Compared to vehicle controls (Con) (A), morphine and Tat (Morph+Tat) (B) caused significant reductions in dendritic length (*P < 0.05 vs. vehicle controls) (E). Fractalkine prevented Morph+Tat-induced dendritic pruning (^#P < 0.05 vs. Morph+Tat) (D,E), but by itself had no effect (C,E). Data in E are mean dendrite length (μm) ± SEM from n = 4 experiments; scale bar = 20 μm.