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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

Figure 1

Amyloid precursor protein (APP) processing pathway [30–62]. AICD, AβPP intracellular domain; C83 (C99), carboxy-terminal fragments C83 (C99); DR6, death receptor 6; LRP, lipoprotein receptor-related protein; sAPP, secreted AβPP fragment; TTR, transthyretin. Degradation, see 'Clearance of Aβ' of the text for details. Involvement of TTR regulation: it has been suggested that APP or its fragments up-regulate TTR [169, 171, 230].

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Molecular Neurodegeneration

ISSN: 1750-1326