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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

Figure 2

Proposed mechanisms of TTR inhibition of Ab toxicity. TTR inhibition of Aβ aggregation (fibril formation) was reported by many groups [12, 158, 169, 203205] and current evidence suggested that the binding is mediated by association of monomeric TTR to Aβ. It is also possible that TTR facilitates Aβ degradation directly [208] or indirectly, transports of Aβ from CNS into serum (plasma sink hypothesis) [12, 202]. TTR may also inhibit Aβ production by inhibition of γ-secretase cleavage [169].

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