Skip to main content
Figure 7 | Molecular Neurodegeneration

Figure 7

From: Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

Figure 7

Possible Role of GPX4 in Prevention of Apoptotic Cell Death and Production of Neuromelanin. In healthy DA neurons, GPX4 functions to reduce oxidized lipids by oxidizing glutathione (GSH) to glutathione disulfide (GSSG) (above). However, a buildup of oxidized dopamine metabolites or a reduction of glutathione may lead to the synthesis of neuromelanin by GPX4, a process that could compete with reduction of oxidized lipids (below). The accumulated oxidized lipids will be metabolized by 12/15-lipoxygenase (12/15-lipoxy) and may eventually induce AIF and promote apoptotic cell death of DA neurons.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326