Skip to main content
Figure 7 | Molecular Neurodegeneration

Figure 7

From: Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

Figure 7

Immunohistochemical analysis of brain sections from transgenic mice at different ages: In order to determine whether there is accumulation of P-APP in the brain mice at 1.5 and 6 months were analysed using 6E10 and P-APP antibodies. Brain sections from transgenic mice showed an increase in overall staining using the 6E10 and P-APP antibodies (A-D). Panel A shows brain sections from 1.5 month old mice where P-APP showed beaded staining of neurites occasionally in APP and PS/APP mice. 6E10 staining showed APP in the neuronal bodies in these sections. The enlarged P-APP positive neurites are shown in panel B. Panel C shows examples of neurons in APP mice at 6 months that show P-APP accumulation. Panel D shows the P-APP and 6E10 staining in 6 month old Ntg, APP, and PS/APP mice. The accumulation of Aβ and P-APP are visible only in the PS/APP mice at 6 months. Panel E shows the magnification of the area shown with the arrows from 6E10 and P-APP stained PS/APP sections. Images in panel A were taken at 10× and in panel B at 20 × magnifications. Images shown in Panel D were taken at 5× magnification.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326