Dantrolene protects YAC128 MSNs from glutamate-induced apoptosis. Quantification of glutamate-induced apoptotic cell death of cultured 14DIV YAC128 (closed) and WT (open) MSNs, with (red) or without (black) 1 h dantrolene (Dan) pre-treatment. Shown are the mean ± SE of % TUNEL positive cells = (number of TUNEL positive MSNs/number of MSNs) × 100%. n = number of fields counted, Stats. WT, wild type; Q128, YAC128.