Figure 3

Dantrolene feeding improves performance of YAC128 mice in the beam-walk test. Motor coordination performance of WT and YAC128 mice in dantrolene trial. A-F. Beam walk assay. The average time to cross the beam (A, C, E) and the average number of foot slips on the beam (B, D, F) are shown for beam-walking experiments performed with 17 mm round plastic beam (A, B), 11 mm round plastic beam (C, D), and 5 mm square wood beam (E, F). The data for WT control mice (open black circles), YAC128 control mice (open red circles), WT mice fed with dantrolene (filled black circles), and YAC128 mice fed with dantrolene (filled red circles) are shown as mean ± SE (for the numberof mice (10) in each experimental group, see Table 2) 2, 4, 7, 9.5, 11.5, and 13.5 (washout) months of age. While counting the foot slips of the mice with "crawling behavior, " we considered every step as one foot slip. *p < 0.05, significant differences between control WT group and control SCA3 group. "xF" on C and E mouse fell off the beam and failed the test where x = number of mice. *p < 0.05 using one-way ANOVA with Tukey's post test. WT, wild type; YAC, YAC128; Ctrl, control; Dan, dantrolene.