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Table 1 Effects of dantrolene on glutamate-induced apoptosis in WT and YAC128 MSN.

From: Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

Dantrolene treatment WT (% TUNEL-positive) YAC128 (% TUNEL-positive)
  0 μM glutamate 250 μM glutamate 0 μM glutamate 250 μM glutamate
Control 1 5.20 ± 1.16 32.22 ± 2.66 5.94 ± 1.11 57.45 ± 5.62
0.01 μM 7.45 ± 1.08 32.02 ± 2.28 7.13 ± 1.37 52.03 ± 5.45
0.1 μM 4.92 ± 1.48 31.36 ± 3.64 5.73 ± 0.87 40.37 ± 3.18*
Control 2 16.43 ± 1.25 37.43 ± 3.66 17.05 ± 1.18 73.26 ± 3.32
1.0 μM 14.05 ± 0.68 37.61 ± 2.75 21.76 ± 2.60 50.45 ± 4.11***
10 μM 17.22 ± 1.39 34.69 ± 1.86 18.75 ± 1.92 42.79 ± 2.85***
50 μM 17.94 ± 0.95 38.20 ± 2.21 19.73 ± 1.67 35.85 ± 2.24***
  1. ***p < 0.001 compared to Control 2, *p < 0.05 compared to Control 1 using one-way ANOVA with Tukey's post test.