Table 1 Effects of dantrolene on glutamate-induced apoptosis in WT and YAC128 MSN.
From: Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
Dantrolene treatment | WT (% TUNEL-positive) | YAC128 (% TUNEL-positive) | ||
|---|---|---|---|---|
|  | 0 μM glutamate | 250 μM glutamate | 0 μM glutamate | 250 μM glutamate |
Control 1 | 5.20 ± 1.16 | 32.22 ± 2.66 | 5.94 ± 1.11 | 57.45 ± 5.62 |
0.01 μM | 7.45 ± 1.08 | 32.02 ± 2.28 | 7.13 ± 1.37 | 52.03 ± 5.45 |
0.1 μM | 4.92 ± 1.48 | 31.36 ± 3.64 | 5.73 ± 0.87 | 40.37 ± 3.18* |
Control 2 | 16.43 ± 1.25 | 37.43 ± 3.66 | 17.05 ± 1.18 | 73.26 ± 3.32 |
1.0 μM | 14.05 ± 0.68 | 37.61 ± 2.75 | 21.76 ± 2.60 | 50.45 ± 4.11*** |
10 μM | 17.22 ± 1.39 | 34.69 ± 1.86 | 18.75 ± 1.92 | 42.79 ± 2.85*** |
50 μM | 17.94 ± 0.95 | 38.20 ± 2.21 | 19.73 ± 1.67 | 35.85 ± 2.24*** |