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Table 2 Brain weight and MSN counts of 14 months old WT and YAC128 mice.

From: Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

Group name

Number of female mice

Brain weight (g)

MSN counts (106)

WT-Ctrl

10

0.499 ± 0.01

1.27 ± 0.03

WT-Dan

10

0.495 ± 0.01

1.263 ± 0.03

YAC128-Ctrl

10

0.437 ± 0.01***

0.997 ± 0.03*

YAC128-Dan

10

0.461 ± 0.01

1.18 ± 0.030#

  1. The brain weight and MSN counts from NeuN staining and stereological analysis are shown as mean ± SE. ***p < 0.001, *p < 0.05 compared to WT-Ctrl and #p < 0.05 compared to YAC128-Ctrl using one-way ANOVA with Tukey's post test.
  2. Pathological analysis of WT and YAC128 mice tissues following dantrolene trial.
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Molecular Neurodegeneration

ISSN: 1750-1326