Table 2 Enriched functional categories for genes differentially regulated by α-synuclein
Database identifier | Functional category (Enriched GO and GAD terms) | Number of changed genes | ||
|---|---|---|---|---|
| Â | Â | up | down | pvalue |
MF SP_PIR_KEY | phosphoprotein | 49 | 64 | 8E-07 |
BP GO:0007242 | intracellular signaling cascade | 11 | 8 | 5E-02 |
BP KEGG_PATH | mmu04010:MAPK signaling pathway | 5 | 4 | 3E-02 |
BP KEGG_PATH | mmu04020:Calcium signaling pathway | 3 | 5 | 1E-02 |
CC GO:0045202 | synapse | 7 | 10 | 3E-06 |
CC GO:0005856 | cytoskeleton | 12 | 10 | 4E-02 |
CC GO:0031410 | cytoplasmic vesicle/vesicle-mediated transporta | 8 | 7 | 1E-02 |
BP GO:0048167 | regulation of synaptic plasticity | 3 | 3 | 4E-04 |
BP GO:0007267 | cell-cell signaling | 4 | 5 | 3E-02 |
BP GO:0006897 | endocytosis | 4 | 3 | 5E-02 |
BP GO:0045941 | positive regulation of transcription | 5 | 10 | 3E-03 |
BP GO:0042127 | regulation of cell proliferation | 8 | 9 | 2E-03 |
MF GO:0005520 | IGF binding/growth factor bindingb | 1 | 4 | 7E-03 |
BP GO:0051259 | protein oligomerization | 2 | 3 | 1E-02 |
BP GO:0042981 | regulation of apoptosis | 6 | 11 | 2E-03 |
BP GO:0007610 | behavior | 10 | 13 | 7E-04 |
BP GO:0007626 | locomotory behavior | 5 | 8 | 4E-03 |
BP GO:0008344 | adult locomotory behavior | 1 | 4 | 8E-03 |
BP GO:0007631 | feeding behavior | 5 | 7 | 5E-04 |
BP GO:0001975 | response to amphetamine | 2 | 1 | 2E-02 |
BP GO:0030146 | diuresis/excretionc | 3 | 1 | 2E-03 |
MF GO:0005179 | hormone activity | 1 | 5 | 2E-02 |
BP GO:0016125 | sterol metabolic process/cholesterol metabolismd | 5 | 4 | 2E-02 |
BP GO:0030182 | neuron differentiation | 10 | 10 | 9E-07 |
BP GO:0031175 | neuron projection development | 7 | 6 | 2E-05 |
BP GO:0001944 | vasculature development | 2 | 6 | 4E-02 |
D G_A_DB_D | neurological diseases | 4 | 5 | 5E-02 |
D G_A_DB_D | diabetes, types 1 and 2 | 3 | 6 | 5E-02 |