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Table 3 α-synuclein-regulated genes associated with neurological or vascular diseases

From: Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

Hs orthologs Affymetrix (HGU-133A)

Gene symbol: short description

ASO mice

Neurological disease

  

fold change

p- value

 

200862_AT

Dhcr24: 24-dehydrocholesterol reductase

6.1

2E-05

AD

206590_X_AT

Drd2: dopamine receptor D2

3.3

8E-05

Al, BD, Diab.

206713_AT

Ntng1: netrin G1

2.5

2E-04

Sch.

212762_S_AT

Tf7l2: transcription factor 7-like 2

2.1

2E-04

Diab.

205013_S_AT

Adora2a: adenosine A2a receptor

2.0

2E-05

Anx, ADHD,

201847_AT

Lip1: lipase 1, cholesterol esterase

1.9

2E-03

AD

218489_S_AT

Alad: aminolevulinate, δ-dehydratase

1.5

2E-04

ALS, Al, Pb Tx

203146_S_AT

Gabbr1: γ-aminobutyric acid receptor 1

1.5

4E-04

ADHD, Ep, Sc.

211026_S_AT

Mgll: monoglyceride lipase

1.5

2E-05

Al.

209702_AT

Fto: fat mass and obesity associated

1.5

1E-03

Diab.

212560_AT

Sorl1: sortilin-related receptor, LDLR class A

-1.5

3E-05

AD

210381_S_AT

Cckbr: cholecystokinin B receptor

-1.5

3E-03

PD, Sc, Diab.

205525_AT

Cald1: caldesmon 1

-1.5

1E-03

Diab.

212382_AT

Tcf4: transcription factor 4

-1.5

3E-03

Sc.

209189_AT

Fos: FBJ osteosarcoma oncogene

-1.6

6E-04

AD

203293_S_AT

Lman1: lectin, mannose-binding, 1

-1.6

2E-03

At, CAD, Inf. D

209101_AT

Ctgf: connective tissue growth factor

-1.6

7E-05

Diab.

216248_S_AT

Nr4a2: nuclear receptor subfamily. 4, group A, member 2

-1.7

5E-05

PD, ADHD, BD,

201348_AT

Gpx3: glutathione peroxidase 3 (plasma)

-1.9

2E-04

Diab.

204729_S_AT

Stx1a: syntaxin 1A (brain)

-1.9

2E-05

Diab.

202291_S_AT

Mglap: matrix Gla protein

-2.0

2E-05

At, Pb Tx

206577_AT

Vip: vasoactive intestinal peptide

-2.0

2E-05

MS

207848_AT

Avp: arginine vasopressin

-2.0

2E-05

Diab., Dement.

205352_AT

Serpina3n/serpin p. inhibitor, cl. A member 3n

-2.8

3E-05

Dement.

206622_AT

Thr: thyrotropin-releasing hormone

-8.0

1E-03

Hypertension

215775_AT

Thbs1: thrombospondin 1

-13.0

7E-04

At, CAD

212412_AT

Pdzl: PDZ and LIM domain 5

-16.0

3E-04

BD, Sc.

  1. Abbreviations: D: Disease/Disorder; ADHD: Attention deficit hyperactivity D; AD: Alzheimer's D; Al: Alcoholism; ALS: Amyotrophic lateral sclerosis; Anx: Anxiety D; At: Atherosclerosis; BD: Bipolar D.; CAD: Coronary artery D; Dement: Dementia; Diab: Diabetes; Ep: Epilepsy; Hs: Homo sapiens; Inf. D: Inflammatory D; MS: Multiple sclerosis; Pb Tx: Lead toxicity; PD: Parkinson's D.; Sc: Schizophrenia