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Table 1 Summary of neurogenesis changes in transgenic mouse models of AD

From: Adult hippocampal neurogenesis and its role in Alzheimer's disease

Genetic Manipulation

Strain Name

Genotype

Promoter

Age (mon)

Pathology

(Aβ deposition)

Neurogenesis assessment

Effect

Reference

Knock-in

 

mo PS1M146V/-

 

3

 

BrdU injection twice daily (2 hr apart) for 4 consecutive days

Decreased proliferation and differentiation

[36]

  

hu ApoE4

 

3, 6-7, 12-13

 

BrdU injection twice (6 hr apart)

Diminished neuronal maturation

[41]

  

mo APPswe/PS1ΔE9

 

8-9

18-24

post

DCX, MCM2 immunostaining

Decreased proliferation

[42]

Transgenic

 

hu PS1P117L

NSE

3-4

 

one BrdU injection per day for 12 consecutive days

Decreased survival

[37]

  

hu PS1ΔE9, hu PS1M146L

PrP

3

 

single injection of BrdU

Decreased proliferation and differentiation

[38]

 

Tg2576

chimeric mo-hu APPswe

PrP

12-14

pre

five daily injections of BrdU

Decreased proliferation, survival and differentiation

[39]

 

PDAPP

hu APPind

PDGF

2

12

pre

post

one i.p. injection of BrdU

Decreased proliferation and survival

[40]

 

APP/PS1

chimeric mo-hu APPswe/hu PS1ΔE9

PrP

6

pre, post

BrdU injection once daily for 12 consecutive days

Decreased survival

[43]

 

APP/PS1

chimeric mo-hu APPswe/hu PS1ΔE9

PrP

2

pre

BrdU injection every 12 hr for 3 days

Decreased proliferation and differentiation

[44]

 

3xTg-AD

hu APPswe/PS1M146V/tauP301L

Thy-1.2

4, 9

  

Decreased proliferation

[45]

 

J20

hu APPswe, ind

PDGF

3, 12

pre, post

BrdU injection twice daily (8 hr apart) for 3 consecutive days

Increased proliferation and differentiation

[46]

 

J20

hu APPswe, ind

PDGF

3, 5, 9, 11

pre, post

daily injection of BrdU for 5 days

Increased proliferation and differentiation

[47]

 

J20

hu APPswe, ind

PDGF

2-3

pre

BrdU injection for 3 days

Accelarated early development but impaired late maturation of newborn neurons

[48]

Knock-out

 

ApoE

 

3, 6-7, 12-13

 

BrdU injection twice (6 hr apart)

Reduced neurogenesis but increased astrogenesis

[41]

  

PS1/PS2 forebrain KO

 

7-9

18-20

 

single dose injection of BrdU

Enhanced cell proliferation at early stages of neurodegeneration but impaired survival at late stages

[49]