From: Adult hippocampal neurogenesis and its role in Alzheimer's disease
Genetic Manipulation | Strain Name | Genotype | Promoter | Age (mon) | Pathology (Aβ deposition) | Neurogenesis assessment | Effect | Reference |
---|---|---|---|---|---|---|---|---|
Knock-in | Â | mo PS1M146V/- | Â | 3 | Â | BrdU injection twice daily (2 hr apart) for 4 consecutive days | Decreased proliferation and differentiation | [36] |
 |  | hu ApoE4 |  | 3, 6-7, 12-13 |  | BrdU injection twice (6 hr apart) | Diminished neuronal maturation | [41] |
 |  | mo APPswe/PS1ΔE9 |  | 8-9 18-24 | post | DCX, MCM2 immunostaining | Decreased proliferation | [42] |
Transgenic | Â | hu PS1P117L | NSE | 3-4 | Â | one BrdU injection per day for 12 consecutive days | Decreased survival | [37] |
 |  | hu PS1ΔE9, hu PS1M146L | PrP | 3 |  | single injection of BrdU | Decreased proliferation and differentiation | [38] |
 | Tg2576 | chimeric mo-hu APPswe | PrP | 12-14 | pre | five daily injections of BrdU | Decreased proliferation, survival and differentiation | [39] |
 | PDAPP | hu APPind | PDGF | 2 12 | pre post | one i.p. injection of BrdU | Decreased proliferation and survival | [40] |
 | APP/PS1 | chimeric mo-hu APPswe/hu PS1ΔE9 | PrP | 6 | pre, post | BrdU injection once daily for 12 consecutive days | Decreased survival | [43] |
 | APP/PS1 | chimeric mo-hu APPswe/hu PS1ΔE9 | PrP | 2 | pre | BrdU injection every 12 hr for 3 days | Decreased proliferation and differentiation | [44] |
 | 3xTg-AD | hu APPswe/PS1M146V/tauP301L | Thy-1.2 | 4, 9 |  |  | Decreased proliferation | [45] |
 | J20 | hu APPswe, ind | PDGF | 3, 12 | pre, post | BrdU injection twice daily (8 hr apart) for 3 consecutive days | Increased proliferation and differentiation | [46] |
 | J20 | hu APPswe, ind | PDGF | 3, 5, 9, 11 | pre, post | daily injection of BrdU for 5 days | Increased proliferation and differentiation | [47] |
 | J20 | hu APPswe, ind | PDGF | 2-3 | pre | BrdU injection for 3 days | Accelarated early development but impaired late maturation of newborn neurons | [48] |
Knock-out | Â | ApoE | Â | 3, 6-7, 12-13 | Â | BrdU injection twice (6 hr apart) | Reduced neurogenesis but increased astrogenesis | [41] |
 |  | PS1/PS2 forebrain KO |  | 7-9 18-20 |  | single dose injection of BrdU | Enhanced cell proliferation at early stages of neurodegeneration but impaired survival at late stages | [49] |