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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy

Figure 4

In vivo live imaging of CAA amyloid deposits through closed cranial window. Closed cranial windows were prepared on the right parietal bone of 16 month-old Tg2576 mice and the congophilic amyloid binding dye methoxy-X04 (X04) was administered (6 mg/kg i.p.). On the next day, 2 μM resorufin (dissolved in artificial CSF) was superfused over the brain through a closed cranial window for 5 min. After washing with artificial CSF for 10 min, live fluorescent images of resorufin (red) and X04 (blue) were taken (N = 6). Resorufin selectively labels amyloid deposits in arterioles (arrowheads) but not neuritic plaques (arrows), whereas methoxy-X04 staining is present in both. Scale bars: 100 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326