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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice

Figure 2

Overexpression of p23 in forebrain, cerebellum, brainstem, and spinal cord of Hup23 mice. A, Representative Western blots analysis of steady-state p23 levels in Hup23 mice and littermates. Ninety ÎĽg of total protein lysates (or 15 ÎĽg in the case of line 61) were fractionated on 4-20% SDS-PAGE gels and immunoblotted using polyclonal p23, p24 and flotillin-2 antibodies. B, Quantification of p23 levels. The signal intensity of p23 from multiple animals from each line (normalized to flotillin-2 signal as loading control) was quantified using Odyssey Imager (LI-COR) and plotted as fold difference in Hup23 mice relative to their Ntg littermates.

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Molecular Neurodegeneration

ISSN: 1750-1326