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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice

Figure 4

Movement problem of Hup23 mice. A, Three male F1 littermates of line 06 at the age of P55 are shown for comparison of body size. B, Progressive decline in body weights in Hup23 animals. The weight of each Hup23 animal was compared to the average weight of its own Ntg littermate(s) of the same sex, and the mean ± SEM of 4-7 animals from each line are plotted. C, The average body weight of Hup23 mice and their littermates in each line on the last day of measurement (see B) is plotted as mean ± SEM. A one-way ANOVA with Tukey post-hoc comparison was performed to assess statistical significance. **, p < 0.01; ***, p < 0.001. D, DigiGait analysis. The performance of Ntg mice on the DigiGait is shown as a black line with open rectangles. Hup23 mice and littermates were subject to DigiGait trial every other day at treadmill speeds of 20 cm/sec or lower as described under Methods. The animals were tested at lower speeds if they were too impaired to keep up with the treadmill kept at 20 cm/sec. If a mouse failed to gain speed and run when the treadmill was kept at 5 cm/sec, 0 cm/sec is rendered to that trial and the animal was not tested any further. Each black circle represents the average speed at which Hup23 mice can run at a given age. The mean ± SEM of data from 14 Hup23 Tg mice from 4 lines and Ntg littermates is plotted. A one-sample t-test was performed to compare the speed of Hup23 mice at each age with to the speed of Ntg animal (20 cm/sec). **, p < 0.01; ***, p < 0.0001 for all other ages tested.

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