Figure 7

Although at this age no rotorod deficits were detected in the KI mice relative to WT, curcumin lowered performance scores. At the end of the trial, when tested on the rotarod, both WT (left) and KI (right) mice treated with curcumin showed impaired performance. Data shown are mean ± sem. Groups were composed of balanced mixed gender groups since there was no significant effect of gender (see text). Data were analyzed using ANOVA followed by Fishers LSD post hoc tests. WT n = 28-30, KI n = 15-16 per group. *p < 0.05, ** p < 0.01 compared to genotype-matched controls on the same day.