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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

Figure 8

Curcumin impairs rotarod performance in normal C57Bl/6 J mice, but does not affect forelimb muscle strength, or locomoter activity. Adult mice were fed from 2.7 m until 8 m of age with curcumin, to approximate the duration that CAG140 mice were fed (gestation + neonatal + adult). Curcumin impaired performance in the rotorod in a gender-independent manner (A). At 8 m age curcumin treatment of males by not females was associated with climbing deficits. Overall, females climbed less than males possibly obscuring treatment effects (B). Curcumin improved grip strength at 4.5 m age, but did not affect grip at other ages tested (C). D) Activity in the open field was normal. Data are shown as mean ± sem, n = 10 per group (n = 9 in curcumin-fed females). Data were analyzed using ANOVA followed by Fishers LSD post hoc tests. *p < 0.05, **p < 0.01 compared to control-fed gender-matched mice.

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