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Table 4 Effect of curcumin treatment on climbing behavior and pole task performance in CAG140 KI and WT mice

From: Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

 

Number of climbs (1.5 m)

Time taken to turn (4 m, (s))

 

WT

KI

WT

KI

Control-treated

1.21 ± 0.33

0.14 ± 0.1**

3.01 ± 0.35

5.22 ± 0.84**

Curcumin-treated

0.48 ± 0.17*

0.38 ± 0.18*

3.03 ± 0.32

4.06 ± 0.69

  1. WT n = 26-30, KI n = 14-16, * p < 0.05, ** p < 0.01 compared to control-treated WT (comparisons to WT curcumin not shown, for clarity). Groups were composed of balanced mixed gender groups as there was no significant effect of gender (see text).
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Molecular Neurodegeneration

ISSN: 1750-1326