Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

Table 10 Association of GSTO locus SNP rs4925 with brain GSTO2 expression levels

Tissue	Diagnosis	N	Beta	P-value
Cer	All	371	-0.175	6.88E-19
	AD	196	-0.203	2.23E-12
	Con	175	-0.149	4.91E-08
Tx	All	392	-0.132	4.70E-11
	AD	201	-0.167	3.93E-09
	Con	191	-0.089	2.30E-03

Results of multivariate linear regression analysis testing association of rs4925 with cerebellar (Cer) and temporal cortex (Tx) levels of GSTO2 in the autopsied subjects with AD pathology, those without (Con), and the combined (All) group. N = number of subjects. Beta coefficient and p value of association between the transcript levels and the SNP are shown for each analyzed series.

ISSN: 1750-1326