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Table 5 Association of GSTO locus SNPs with LOAD risk in the older LOAD series with ages > 80 years

From: Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

N (MAF)

rs#

Locus

Series

AD

Control

OR

95% CI

p-value

  

All

1,338 (0.37)

1,604 (0.33)

1.14

1.01-1.30

0.038

  

JS

309 (0.36)

319 (0.34)

1.09

0.85-1.41

NS

  

RS

299 (0.37)

963 (0.33)

1.21

0.98-1.48

0.073

rs156697

GSTO2

AUT

311 (0.40)

99 (0.36)

1.19

0.81-1.75

NS

  

NCRAD

146 (0.37)

86 (0.30)

1.29

0.81-2.05

NS

  

NW

176 (0.33)

116 (0.30)

1.19

0.81-1.76

NS

  

PS

97 (0.38)

21 (0.33)

1.38

0.62-3.11

NS

  

All

1,341 (0.33)

1,595 (0.30)

1.10

0.97-1.25

0.151

  

JS

306 (0.31)

321 (0.30)

1.08

0.23-1.41

NS

  

RS

302 (0.33)

960 (0.30)

1.17

0.95-1.44

0.134

rs4925

GSTO1

AUT

313 (0.35)

99 (0.35)

1.00

0.69-1.46

NS

  

NCRAD

149 (0.34)

80 (0.28)

1.28

0.80-2.05

NS

  

NW

173 (0.30)

114 (0.28)

1.13

0.76-1.70

NS

  

PS

98 (0.35)

21 (0.33)

1.11

0.48-2.58

NS

  1. Results of multivariate logistic regression analysis are shown for each SNP, each series individually and for the combined series. N = number of subjects, MAF = minor allele frequency, OR = odds ratio; NS = not significant.
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Molecular Neurodegeneration

ISSN: 1750-1326