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Table 7 Association of GSTO locus SNPs with LOAD risk in the LOAD series all ages combined

From: Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

N (MAF)

rs#

Locus

Series

AD

Control

OR

95% CI

p-value

  

All

3,490 (0.36)

4,617 (0.34)

1.06

0.98-1.14

0.177

  

JS

853 (0.37)

953 (0.33)

1.19

1.03-1.38

0.021

  

RS

586 (0.35)

2,386 (0.33)

1.07

0.93-1.23

NS

rs156697

GSTO2

AUT

574 (0.38)

353 (0.37)

0.98

0.79-1.22

NS

  

NCRAD

677 (0.35)

205 (0.39)

0.78

0.60-1.02

0.069

  

NW

341 (0.33)

544 (0.30)

1.10

0.87-1.39

NS

  

PS

459 (0.37)

176 (0.35)

1.00

0.75-1.35

NS

  

All

3,489 (0.32)

4,606 (0.31)

1.03

0.95-1.12

NS

  

JS

850 (0.32)

965 (0.30)

1.12

0.96-1.31

0.137

  

RS

591 (0.31)

2,374 (0.31)

1.04

0.90-1.21

NS

rs4925

GSTO1

AUT

578 (0.33)

353 (0.34)

0.89

0.71-1.11

NS

  

NCRAD

671 (0.31)

197 (0.29)

1.01

0.76-1.34

NS

  

NW

331 (0.31)

537 (0.29)

1.03

0.81-1.32

NS

  

PS

468 (0.35)

180 (0.34)

0.93

0.69-1.26

NS

  1. Results of multivariate logistic regression analysis are shown for each SNP, each series individually and for the combined series. N = number of subjects, MAF = minor allele frequency, OR = odds ratio; NS = not significant.