Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

Table 9 Association of GSTO locus SNP rs156697 with brain GSTO2 expression levels

Tissue	Diagnosis	N	Beta	P-value
Cer	All	373	-0.200	1.90E-27
	AD	197	-0.225	1.12E-17
	Con	176	-0.173	1.15E-10
Tx	All	393	-0.146	1.20E-14
	AD	202	-0.166	2.50E-10
	Con	191	-0.119	3.30E-05

Results of multivariate linear regression analysis testing association of rs156697 with cerebellar (Cer) and temporal cortex (Tx) levels of GSTO2 in the autopsied subjects with AD pathology, those without (Con), and the combined (All) group. N = number of subjects. Beta coefficient and p value of association between the transcript levels and the SNP are shown for each analyzed series.

ISSN: 1750-1326