Table 2 Pool Sizes (PS), Fractional Clearance Rates (FCR), Production Rates (PR), and Half-lives for ApoE by Mouse Genotype
Genotype | PS (ng/mg) | FCR (pools/hr) | PR (ng/mg/hr) | Half-life (t1/2, hrs) |
|---|---|---|---|---|
Wt (LDLR Tg control) | 125.4 ± 9.1 | 0.093 ± 0.011 | 11.69 ± 1.64 | 7.5 |
LDLR Tg | 44.7 ± 1.9 | 0.25 ± 0.019 | 11.07 ± 0.96 | 2.8 |
P | <0.0001 | <0.0001 | 0.75 | |
Wt (ABCA1 Tg control) | 135.5 ± 4.8 | 0.10 ± 0.019 | 14.08 ± 1.64 | 6.9 |
ABCA1 Tg | 109.2 ± 3.8 | 0.15 ± 0.022 | 16.81 ± 0.96 | 4.6 |
P | <0.0001 | 0.106 | 0.46 | |
Wt (ABCA1 −/− control) | 230.5 ± 12.1 | 0.09 ± 0.015 | 20.76 ± 3.64 | 7.7 |
ABCA1 −/− | 117.6 ± 8.0 | 0.17 ± 0.010 | 20.41 ± 2.13 | 4.1 |
P | <0.0001 | <0.0001 | 0.94 |