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Table 3 Pool Sizes (PS), Fractional Clearance Rates (FCR), Production Rates (PR), and Half-lives for Aβ by Mouse Genotype

From: Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Genotype

PS (pg/mg)

FCR (pools/hr)

PR (pg/mg/hr)

Half-life

(t1/2, hrs)

Wt (ABCA1 Tg control)

11.23 ± 0.56

0.238 ± 0.016

2.65 ± 0.21

2.91

ABCA1 Tg

11.14 ± 0.46

0.247 ± 0.016

2.77 ± 0.23

2.81

P

0.90

0.69

0.68

 

Wt (ABCA1 −/− control)

7.67 ± 0.26

0.247 ± 0.023

1.91 ± 0.15

2.81

ABCA1 −/−

7.87 ± 0.33

0.243 ± 0.016

1.89 ± 0.19

2.85

P

0.64

0.88

0.94

 
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Molecular Neurodegeneration

ISSN: 1750-1326