Figure 5From: The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalitiesReduced striatal catecholamines in I2020T LRRK2 TG mice. (A) Striatal concentrations of dopamine and its metabolites, DOPAC and HVA. Concentrations of catecholamines were determined by HPLC and electrochemical detection (NTG, n=6; TG, n=6; 10 weeks). (B) Striatal TH activity. The TH enzymatic activity was determined by measuring the amount of L-dopa. The vertical scales indicate the ratio of L-dopa in TG mice relative to that in NTG mice (NTG, n=3; TG, n=3; 10 weeks). Quantitative data are expressed as mean ± SEM and were assessed by Student’s t test; *p<0.05.Back to article page