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Figure 5 | Molecular Neurodegeneration

Figure 5

From: The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

Figure 5

Reduced striatal catecholamines in I2020T LRRK2 TG mice. (A) Striatal concentrations of dopamine and its metabolites, DOPAC and HVA. Concentrations of catecholamines were determined by HPLC and electrochemical detection (NTG, n=6; TG, n=6; 10 weeks). (B) Striatal TH activity. The TH enzymatic activity was determined by measuring the amount of L-dopa. The vertical scales indicate the ratio of L-dopa in TG mice relative to that in NTG mice (NTG, n=3; TG, n=3; 10 weeks). Quantitative data are expressed as mean ± SEM and were assessed by Student’s t test; *p<0.05.

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