Figure 1

Levels of p3-Alc _α , Aβ40, and Aβ42, and Aβ42/40 ratios in CSF of three cohorts. (A) Cohort 1 (Japan). Non-demented healthy controls (CDR 0, n = 18), very mild AD subjects (CDR 0.5, n = 20), AD subjects with mild dementia (CDR 1, n = 13) and AD subjects with moderate dementia (CDR 2, n = 13) were analyzed for levels of p3-Alc_α (left) and Aβ40 (middle left), Aβ42 (middle right) and Aβ42/40 ratio (right). (B) Cohort 2 (USA). Non-demented healthy controls (CDR 0, n = 20), MCI subjects (CDR 0.5, n = 20) and AD subjects with mild dementia (CDR 1, n = 13) were analyzed for levels of p3-Alc_α (left) and Aβ40 (middle left), Aβ42 (middle right) and Aβ42/40 ratio (right). Dashed line on the middle right panel indicates cut-off value of Aβ42 (500 pg/mL). (C) Cohort 3 (Japan). Non-demented healthy controls (CDR 0, n = 23), MCI subjects (CDR 0.5, n = 9), AD subjects with mild dementia (CDR 1, n = 13) and AD subjects with moderate and severe dementia (CDR 2–3, n = 12), and FTLD subjects (n = 37) of Japanese cohort (Cohort 3) were analyzed for levels of p3-Alc_α (left) and Aβ40 (middle left), Aβ42 (middle right) and Aβ42/40 ratio (right). Statistical analysis was performed using the Dunn's multiple comparisons test following the Kruskal-Wallis test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.